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Protein & Cell ; (12): 240-260, 2021.
Artigo em Inglês | WPRIM | ID: wpr-880931

RESUMO

Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which has been previously identified as a transporter for cholesterol, plays a pivotal role in regulating CD8

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